I don't remember that one?
X-Men and Blade's timelines probably diverged in 5th millenium BCE. The birth of Vampires via Deviants in 5000 BC. Mutants are born from some interferences from Celestials and Victor Timely's Rama-Tut variant (who was forced to leave behind his advanced tech that En Saber Nur would later use for himself).
Amazing Spider-Man has a Captain America, as noted from the video games' own divergent timeline, so the Super Soldier Serum was a success and the timeline for Ben and May's family history differs starting from directly after WW2.
Hulk (2003), I guess if you wanna argue young Ross in the opening flashbacks is really rough 19-20 year old, also deviates (in the early 60s) as a result of the Super Soldier Serum. Ross' superiors are wanting a new version of the Serum and I guess Bruce Banner's dad became an abusive dickhead due to the stress of working for the military.
Daredevil/Elektra is another result of family history and "time-of-conception" related butterfly effects. Ditto for Tim Story's Fantastic Four and Fant4stic, plus both previous Punishers (Thomas Jane and Ray Stevenson).
Ghost Rider's timeline deviates sometime after the point where Johnny Blaze makes the deal in 1986 and what decided to do with his life here instead of the Sacred Timeline.