So at Paley Fest, the AoS cast, writers, and producers appeared and aired episode 16 "End of the Beginning" (which airs next week, April 1). A question and answer session led to Jeph Loeb being asked about how AoS ties into Cap-TWS, and his reply was to watch Episode 16 (April 1) and Episode 17 (April 8 ).
Many are speculating that episode 16 "End of the Beginning" leads directly into Captain America - The Winter Soldier, with episode 17 "Turn, Turn, Turn" likely picking up immediately after TWS and possibly continuing with the reveal of the Clairvoyant's identity (rumored to be revealed in TWS). So does this mean we'll see some of the film's stars showing up on AoS? Remains to be seen, but it's very likely, especially considering Loeb played coy when asked directly, and Deathlok returns in "End of the Beginning", likely setting up for the Clairvoyant's debut on the show in the following episode or possibly later in the season.
Now, normally I'd assume they'd save the Clairvoyant reveal for the season finale, but given that's not until mid-May, and they're obviously using the Cap 2 film to attract viewers to AoS, and AoS to advertise Cap 2, it'll be interesting to see what surprises they do have in store for the finale, since I'm 99% sure we'll get the reveal in CA-TWS and on AoS in Episode 17. Which if this holds true, it'll likely be setting up something else for the last "arc" of the season (Episodes 16-22).
I'm guessing it'll relate to the blue alien/Kree that Coulson discovered in T.A.H.I.T.I., possibly with more info shed on how SHIELD obtained the alien body, details on its effects on those it's administered to (Coulson and Skye), and the repercussions of what that serum will do to them.
If Mike Peterson as Deathlok proved anything, it's that the MCU heroes may not always have their comic counterparts' actual first and last name, so as to keep fans guessing. So, does this mean Coulson and/or Skye may end up being superheroes (or at least super-powered individuals)? Well, that remains to be seen.
I think Coulson is and always will be Coulson, possibly displaying no powers beyond being resurrected due to the alien blood. However, given Skye's being an 084, in combination with the alien blood, may indeed lead to her developing powers. And if that was indeed a Kree (which would be nice timing to set up a tie in to Guardians of the Galaxy), which seems the most likely option, could Skye end up being Captain Marvel/Ms. Marvel?
It would make sense if that is a Kree, but part of me doesn't want Skye to be Captain/Ms. Marvel. It just doesn't feel right. For one, Captain/Ms. Marvel seems like a female character well suited for her own film, and I'm not sure her starting out as a hacker, then SHIELD agent in training, and eventual super hero works or flows naturally in any way.
But then again, who knows (besides Jeph Loeb, Jed Whedon, Maurissa Tanchereon, Joss Whedon, Kevin Feige, and the other MCU bigwigs or show writers/producers)? We'll have to wait and see, but it's fun to speculate.