Nope. They're new.
Given that this is the first ish of a six-issue arc that's introducing completely new bad guys, I think it did the job well. I honestly dig the designs and the personalities of these new characters. They're sympathetic baddies who'll really set the stage for the sickness of the real threats. Plus, the one dude using his powers to create monsters out of synthetic materials is about the most awesome thing ever.
Even more important, Carey reaffirmed what he proved in the Annual. He totally gets the characters. With Millar, a lot of the time I felt like the members of the Fantastic Four were just a vehicle for the story. There are some exceptions naturally. Grimm was pretty well played in President Thor, and Doom was a total badass. But Carey, I think, gets the personalities of the Four better than any of the writers on the book, yet. And even more important, he's got their banter down to a science. The characters are a family, and they should always be playing off of each other. I think Carey does that phenomenally.
So, he's proven he gets the core of the team, and he's set up some interesting low-tier baddies to set the stage for the latter parts of the story. I think he did everything that needs to be done for the first issue. I have high hopes.
Plus, Johnny finally lost that stupid hair cut.