I'm really tired of vampire stories.  Specifically the kind where they're depicted as good guys.  They're getting really, really old.
Gaiman here says my thought on the matter pretty well:
http://www.ew.com/ew/article/0,,20301186,00.html
(Hellsing was good though.  So was Karin when I stopped thinking of it as a vampire story.)
(Incidentally and possibly hypocritically, I'd like to see a story where a Van Helsing sort-of dude goes around killing vampires while refusing to believe they exist and that he fights them on a regular basis.  Like say, he'd be in deadly combat with a skanky vampiress and he'd say "Gee, I should see a doctor about these strange, fistfight-like seizures.  And that erectile dsyfunction."  It'd be hilarious.)